Glioblastoma multiforme (GBM) is the most common primary brain malignancy, having an annual incidence of 3.19 per 100,000 population. Keywords: bevacizumab, FET, fluoroethyl tyrosine, glioblastoma, MRI, PET High posttreatment-to-pretreatment FET PET uptake ratio and increase in correlation between PET uptake and contrast-enhanced T1 signal intensity after bevacizumab treatment are associated with poor PFS and OS. There is only a moderate correlation between FET PET uptake and contrast-enhanced T1 signal intensity. The increase in correlation between PET uptake and contrast-enhanced T1 intensity after treatment was associated with lower PFS ( p < 0.001) and OS ( p = 0.049).ĬONCLUSION. A post-treatment to pretreatment PET uptake ratio (mean and 90th percentile) greater than 0.7 for both entire and enhancing tumor was associated with lower PFS and OS ( p < 0.001–0.049). The median PFS after initiation of bevacizumab therapy was 111 days, and the OS was 223 days. Mean Spearman correlation between FET uptake and contrast-enhanced T1 signal intensity before therapy was 0.65 and after therapy was 0.61 ( p = 0.256). Voxel-wise Spearman correlation between normalized FET uptake and contrast-enhanced T1 signal intensity was assessed and tested as a predictor of PFS and OS. The ratio between normalized FET uptake at follow-up and baseline of the entire (volume of T2 FLAIR abnormality) and enhancing tumor were assessed for prediction of progression-free survival (PFS) and overall survival (OS). MRI and FET PET were performed before and after administration of two doses of bevacizumab to 11 patients with recurrent glioblastoma. The aim of this study was to assess the utility of 18F-fluoroethyl-L-tyrosine (FET) PET in the evaluation of recurrent glioblastoma treated with bevacizumab. In MRI of patients with recurrent glioblastoma, bevacizumab-induced normalization of tumor vascularity can be difficult to differentiate from antitumor effects.
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